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低温铝电解 2

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Cancer and the environment: Filling knowledge gaps together

Linda S. BIRNBAUM PhD, DABT, ATS,

《医学前沿（英文）》 2010年第4卷第2期页码 131-133 doi: 10.1007/s11684-010-0044-3

摘要： When considering disease etiology, we need to view the role of the environment along the continuum from health to disease for individuals because we know that there are complex interactions between genes, their molecular expression, and environmental factors over a person’s lifetime. We clearly have huge gaps in our knowledge along this continuum, and these gaps are natural opportunities for research. There are many factors to consider as we assess the relationship between environmental exposures over a lifetime. One factor is persistence of chemicals that “live” beyond their initial intended use. Another factor is the fact that “inert ingredients” are not really inert. “Low dose” is also another consideration. We need to understand the biological effect of low dose exposure and we should clearly define what they mean by low dose research. For example, are we measuring the administered dose, or the internal/circulating dose? There are new types of toxicity as well. For example, endocrine disruptors and engineered nanomaterials are significant classes of materials deserving significant research. Timing of exposure is a significant feature in characterizing toxicity. Environmental exposures can have a greater impact in early or later life-stages. Finally, mixtures of chemicals are an important consideration. Humans are always exposed to multiple chemicals. In short, we must remember that there is no such thing as “not exposed.” Everyone has been exposed to many and various environmental agents.

关键词： environment genes environmental exposure environmental agent persistence chemicals inert ingredients low dose

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中国铝工业应用新型电极材料的研究与展望

邱竹贤

《中国工程科学》 2001年第3卷第5期页码 50-54

摘要：

介绍了现代铝工业上新近开发研制的几种电极材料，涉及惰性阴极、惰性阳极、双极性电极等；还研制了低温电解质，使电解温度降低到800～900℃。如果惰性电极与低温电解质配合起来应用，则能够明显减少工业铝生产中的物料消耗，节省电能，增大电解槽生产能力，并改善环境状况，可望大幅度降低生产成本。

关键词：惰性阳极惰性阴极 SiC绝缘侧壁低温铝电解

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Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

《化学科学与工程前沿（英文）》 2022年第16卷第4期页码 523-535 doi: 10.1007/s11705-021-2083-5

摘要： Solubility has been widely regarded as a fundamental property of small molecule drugs and drug candidates, as it has a profound impact on the crystallization process. Solubility prediction, as an alternative to experiments which can reduce waste and improve crystallization process efficiency, has attracted increasing attention. However, there are still many urgent challenges thus far. Herein we used seven descriptors based on understanding dissolution behavior to establish two solubility prediction models by machine learning algorithms. The solubility data of 120 active pharmaceutical ingredients (APIs) in ethanol were considered in the prediction models, which were constructed by random decision forests and artificial neural network with optimized data structure and model accuracy. Furthermore, a comparison with traditional prediction methods including the modified solubility equation and the quantitative structure-property relationships model was carried out. The highest accuracy shown by the testing set proves that the ML models have the best solubility prediction ability. Multiple linear regression and stepwise regression were used to further investigate the critical factor in determining solubility value. The results revealed that the API properties and the solute-solvent interaction both provide a nonnegligible contribution to the solubility value.

关键词： solubility prediction machine learning artificial neural network random decision forests

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21世纪伊始铝电解工业的新进展

邱竹贤

《中国工程科学》 2003年第5卷第4期页码 41-46

摘要：

21世纪伊始，法国500kA特大型预焙阳极电解槽，以及中国320 kA大型电解槽的出现，标志着铝电解工业的重要新进展。文章从理论上分析了大型电解槽的优越性，论述了减少电解槽的热损失系数，即减少按单位电量核算的热损失量，便是大型槽能够节省电能的理论基础；应用低温铝电解和惰性电极是铝电解工业今后的发展方向。

关键词：铝电解工业大型电解槽低温铝电解惰性阳极和惰性阴极

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铝电解用Fe-Ni-Co-Al₂O₃金属陶瓷惰性阳极

邱竹贤,石忠宁,徐君莉

《中国工程科学》 2004年第6卷第8期页码 35-39

摘要：

研制了一种新型铝电解金属陶瓷惰性阳极，阳极基体由Fe-Ni-CoAl₂O₃构成。在石墨坩埚中，960℃温度下，电解质中的氧化铝质量分数为6.0%，摩尔比为2.6；阳极电流密度为1.0 A/cm²，阳极尺寸大小为120 mm×80 mm×15 mm，石墨阴极尺寸大小为120 mm×40 mm×20 mm，通入的直流电为100～300 A，电解时间各为10 h；实验所得的电解铝产品纯度达到98%以上，杂质主要为Fe，Ni，Co；电解后的阳极外观尺寸无明显变化，阳极气体中氧气质量分数达到98%～99%。阳极的反电动势为2.45 V，比理论分解电压仅高出0.25 V证明该阳极为惰性阳极，在电解槽中进行的是Al₂O₃的分解反应。

关键词：铝电解惰性阳极反电动势

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Degradation of refractory organics in concentrated leachate by the Fenton process: Central composite design for process optimization

Senem Yazici Guvenc, Gamze Varank

《环境科学与工程前沿（英文）》 2021年第15卷第1期 doi: 10.1007/s11783-020-1294-1

摘要： Abstract • 90% total COD, 95.3% inert COD and 97.2% UV254 were removed. • High R2 values (over 95%) for all responses were obtained with CCD. • Operational cost was calculated to be 0.238 €/g CODremoved for total COD removal. • Fenton oxidation was highly-efficient method for inert COD removal. • BOD5/COD ratio of leachate concentrate raised from 0.04 to 0.4. The primary aim of this study is inert COD removal from leachate nanofiltration concentrate because of its high concentration of resistant organic pollutants. Within this framework, this study focuses on the treatability of leachate nanofiltration concentrate through Fenton oxidation and optimization of process parameters to reach the maximum pollutant removal by using response surface methodology (RSM). Initial pH, Fe2+ concentration, H2O2/Fe2+ molar ratio and oxidation time are selected as the independent variables, whereas total COD, color, inert COD and UV254 removal are selected as the responses. According to the ANOVA results, the R2 values of all responses are found to be over 95%. Under the optimum conditions determined by the model (pH: 3.99, Fe2+: 150 mmol/L, H2O2/Fe2+: 3.27 and oxidation time: 84.8 min), the maximum COD removal efficiency is determined as 91.4% by the model. The color, inert COD and UV254 removal efficiencies are determined to be 99.9%, 97.2% and 99.5%, respectively, by the model, whereas the total COD, color, inert COD and UV254 removal efficiencies are found respectively to be 90%, 96.5%, 95.3% and 97.2%, experimentally under the optimum operating conditions. The Fenton process improves the biodegradability of the leachate NF concentrate, increasing the BOD5/COD ratio from the value of 0.04 to the value of 0.4. The operational cost of the process is calculated to be 0.238 €/g CODremoved. The results indicate that the Fenton oxidation process is an efficient and economical technology in improvement of the biological degradability of leachate nanofiltration concentrate and in removal of resistant organic pollutants.

关键词： Concentrated leachate Fenton oxidation Central composite design Biodegradability Inert COD

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Computational design of structured chemical products

Faheem Mushtaq, Xiang Zhang, Ka Y. Fung, Ka M. Ng

《化学科学与工程前沿（英文）》 2021年第15卷第5期页码 1033-1049 doi: 10.1007/s11705-020-2002-1

摘要： In chemical product design, the aim is to formulate a product with desired performance. Ingredients and internal product structure are two key drivers of product performance with direct impact on the mechanical, electrical, and thermal properties. Thus, there is a keen interest in elucidating the dependence of product performance on ingredients, structure, and the manufacturing process to form the structure. Design of product structure, particularly microstructure, is an intrinsically complex problem that involves different phases of different physicochemical properties, mass fraction, morphology, size distribution, and interconnectivity. Recently, computational methods have emerged that assist systematic microstructure quantification and prediction. The objective of this paper is to review these computational methods and to show how these methods as well as other developments in product design can work seamlessly in a proposed performance, ingredients, structure, and manufacturing process framework for the design of structured chemical products. It begins with the desired target properties and key ingredients. This is followed by computation for microstructure and then selection of processing steps to realize this microstructure. The framework is illustrated with the design of nanodielectric and die attach adhesive products.

关键词： product design performance ingredients structure manufacturing process framework structured chemical products microstructure design

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我国铁路工程勘察设计质量指标和因素统计分析

谢洪涛,陈帆

《中国工程科学》 2011年第13卷第4期页码 96-100

摘要：

为深入了解我国铁路勘察设计质量的现状，开展了较大范围的问卷调查工作。调查的内容主要包括两个部分：铁路勘察设计质量的现状以及影响铁路勘察设计质量的主要因素。在问卷调查的基础上，利用SPSS软件对统计数据进行了频数分析、描述性统计分析、相关性分析、因子分析等。通过对调查问卷的统计计算，分析了我国铁路勘察设计质量的现状及存在的主要问题，分析了影响我国铁路勘察设计质量的主要因素，并提出了相应的对策。

关键词：勘察设计质量评价竞争机制主成分相关性分析

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气体分布板开孔结构对流化床干燥性能的影响

刘巍,汤文成

《中国工程科学》 2006年第8卷第2期页码 47-50

摘要：

针对惰性粒子流化床干燥器，以洗衣粉悬浮液为对象，先后进行了气体分布板开直孔和开斜孔的流化干燥实验。通过测定干燥器的流体力学特性曲线，以及在相同进料量、进风温度、进风速度或惰性粒子直径条件下的体积传热系数曲线和热效率曲线，考察和分析了气体分布板两种不同的开孔结构对干燥器流体力学和传热性能的影响。结果表明，气体分布板开斜孔的床内气流阻力要高于开直孔的气流阻力，但其体积传热系数和热效率相对较高，即斜孔较直孔更加有利于床内传热。在此基础上，对惰性粒子流化床干燥器的生产调节措施进行了初步探讨。

关键词：气体分布板开孔结构惰性粒子流化床干燥性能

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气体分布板开孔结构对流化干燥滞留率的影响

刘巍,汤文成

《中国工程科学》 2006年第8卷第6期页码 41-43

摘要：

滞留率是确定流化干燥死床点的重要参数。针对气体分布板开直孔和开斜孔的惰性粒子流化床干燥器，以洗衣粉悬浮液为对象，考查了进料量、惰性粒子直径、进风温度、静床高、进风速度以及物料初始浓度对干燥器滞留率的影响，分析了气体分布板开直孔和开斜孔时干燥器滞留率的大小，并以气体分布板开斜孔为例，测定了干燥器的生产能力与板开孔率之间的关系曲线。结果表明，滞留率随进料量和物料初始浓度的提高而增大，随惰性粒子直径、进风温度、静床高和进风速度的提高而减小；若将气体分布板的孔道由直孔改为斜孔，并在此基础上适当增加板的开孔率，可有效降低干燥器的滞留率，提高干燥器的生产能力。

关键词：惰性粒子流化干燥气体分布板开孔形状开孔率滞留率